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RESET Project

REStore normal hematopoiesis – Stem cells in congenital hematopoietic disorders: from pathogenesis to innovative therapies.

Dear Collaborators, Patients, and Families,

We would like to inform you that at the end of April 2026, the RESET project (REStore normal hematopoiesis – Stem Cells in Congenital Hematopoietic Disorders: From Pathogenesis to Innovative Therapies), funded by the Medical Research Agency under the National Recovery Plan, officially came to an end.

On behalf of the entire research team, we would like to express our sincere gratitude for your commitment, cooperation, and active participation in the implementation of the project. Thanks to your support, it was possible to perform molecular diagnostics of inherited bone marrow failure syndromes in 321 pediatric patients from across Poland and to establish a definitive diagnosis in 107 project participants. In some cases, the diagnostic process is still ongoing, and further results will be communicated to you as they become available.

We hope that the outcomes of the project will contribute significantly to improving the care of patients with inherited hematopoietic disorders and will provide a foundation for future joint clinical and scientific initiatives.

At the same time, we would like to inform you that it is still possible to refer patients with a significant suspicion of inherited bone marrow failure syndromes for molecular diagnostics within the framework of the RESET project, carried out with the support of the Medical University of Lodz. However, due to limited resources, each case will be considered individually.

Therefore, before sending biological material, we kindly ask you to provide a scanned referral form for the candidate for testing (the current template is available in the Referrals section) to the following email addresses: bartosz.urbanski@umed.lodz.pl and/or katarzyna.babol-pokora@umed.lodz.pl

Subsequently, we will inform you regarding the patient’s eligibility for testing.

Once again, we would like to sincerely thank you for your cooperation and the trust you have placed in us.

On behalf of the RESET Project Team
Bartosz Urbański and Wojciech Młynarski
Department of Pediatrics, Oncology and Hematology
Medical University of Lodz

“RESET Project: Stem cells in congenital hematopoietic disorders – from advanced diagnostics to future innovative therapies” under the National Plan for Reconstruction and Enhancement of Immunity, Component D Efficiency, accessibility and quality of the health care system, Investment D3.1.1 Comprehensive development of research in the field of medical and health sciences, contract number 2024/ABM/03/KPO/KPOD.07.07-IW.07-0153/24-00

Ikona STAGE 1
STAGE 1
Recruitment of patients with suspected congenital bone marrow failure. Collection of material for testing (peripheral blood, bone marrow).
Ikona STAGE 2
STAGE 2
Molecular analysis of patient samples. Identification of the genetic basis within known IBMF-associated genes using next-generation sequencing.
Ikona STAGE 3
STAGE 3
If no pathogenic variants are found in step 2, further genetic analysis based on SNP microarrays, whole exome sequencing (WES), and/or optical genome mapping (OGM) is performed. Identification of the putative genetic cause associated with the hematopoietic defect.
Ikona STAGE 4
STAGE 4
Establishing a repository of cryopreserved cells from IBMF patients. Establishing a biobank for further research.
Ikona STAGE 5
STAGE 5
Testing of a genome editing system and viral transduction as a potential therapeutic option in IBMFs.
Ikona kalendarza

Project duration:
March 2025 – March 2026

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